Gingival crevicular fluid levels of sclerostin in chronic periodontitis and healthy subjects
Esfahrood Zeinab Rezaei, Yadegari Zahra, Veysari Setareh Kazemi, Kadkhodazadeh Mahdi,
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( Esfahrood Zeinab Rezaei ) - Shahid Beheshti University of Medical Sciences School of Dentistry Department of Periodontics
( Yadegari Zahra ) - Shahid Beheshti University of Medical Sciences School of Dentistry Department of Dental Biomaterials
( Veysari Setareh Kazemi ) - Shahid Beheshti University of Medical Sciences School of Dentistry
( Kadkhodazadeh Mahdi ) - Shahid Beheshti University of Medical Sciences Dental School Department of Prosthodontics
Abstract
Objectives: Chronic periodontitis is a common inflammatory disease of the oral cavity that causes destruction of periodontal tissues and bone around the teeth. Sclerostin is a protein encoded by the SOST gene. In this study, gingival crevicular fluid (GCF) levels of sclerostin in patients with chronic periodontitis were compared with those of healthy subjects.
Materials and Methods: In this case-control study, a total of 40 subjects were enrolled and divided into the healthy group (n=23) and chronic periodontitis group (n=17). GCF samples were collected, and the concentration of sclerostin was evaluated using enzyme-linked immunosorbent assay. Comparison of significance between groups was assessed using Mann-Whitney U test.
Results: Sclerostin concentration was significantly higher in the chronic periodontitis group compared with the healthy group (P<0.005).
Conclusion: Despite the limitations of this study, sclerostin can be a possible marker for assessment of periodontal health status.
키워드
Sclerostin; Periodontitis; Gingival crevicular fluid
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